Dry Plasma Thawer vs Waterbath

Plasma thawers come as either wet or dry and are specifically designed to agitate frozen cryopreserved products (for speeding up the thawing process).

CytoTherm Dry Plasma Thawers
CytoTherm Dry Plasma Thawers

The method of agitation is more advanced compared to using a traditional waterbath where agitation is not an option. Waterbaths maintain a constant temperature of +37°C the same as plasma thawers, but the lack of agitation means that plasma will take longer to thaw. The disadvantages of a longer thawing period can increase the risk of contamination to the water surrounding the plasma bags via chemicals or bacteria. This has generated much cause for concern over the years and numerous studies have been conducted to establish potential contamination risks and test safer thawing methods.

Dry Plasma Thawer has advantages over the traditional waterbath:

One study – carried out at the University of Kansas Hospital, Kansas City, compared a standard waterbath; the ‘Equitherm 299-733’, and a plasma thawing unit: the ‘Cytotherm® D1’. It was concluded that the dry thawing method exhibited many benefits compared to the waterbath method. 2 important and crucial factors included: reduced contamination, and less cell destruction to plasma products during testing of the CytoTherm D1.

A list of the other benefits collated from the study can be found here: “A comparison of the traditional water-bath vs. dry thawing method for thawing cryopreserved peripheral stem cell components with a goal of reducing the contamination risks”. D.Merkel & T. rieu.

 A dry plasma thawer ensures that bags of plasma are fully protected from direct contact with the water. This method is achieved via leak proof bladders. Another advantage of a dry plasma thawing unit eliminates the need for the operator to handle/manipulate the bags to enhance thawing.

View the latest models of the CytoTherm Dry Plasma Thawing systems .


Leave a Reply